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DMG is an important substance that's found in grains, beans, and meat. It's made from a blend of amino acids that aid in your body's ability to synthesize various nutrients. DMG can also bolster your immunity, reduce stress, and potentially fight the effects of aging. VetriScience® Laboratories’ Vetri DMG™ is a formula to support immune system health and function in dogs, cats and birds. An adaptogen that helps the body cope with various forms of stress, DMG supports performance by enhancing circulation and efficient oxygen utilization. No mountable file systems dmg. Through its ability to lower lactic acid build-up.
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Clinical studies show that DMG supports lymphocyte and antibody production. DMG has been used in both the human and veterinary health worlds for over 30 years with no adverse or negative side effects. Vetri DMG™ is available in a tablet or an easy to administer liquid. In some countries DMG is used as a physical enhancement supplement for athletes and in the Soviet Union it is considered an important nutrient and is used for treating problems such as; alcoholism and drug addiction; mental problems such as those of aging and senility, minimal brain damage in children, autism, and schizophrenia; heart disease and high blood pressure; diabetes; skin diseases; liver disease; and chemical poisonings. Numerous Health Benefits from Taking DMG. The health benefits from supplementing with DMG are significant. Dimethylglycine greatly improves the nutritional environment of the cell, increases immune system function (between up to 300% and 1000%) and improves oxygen utilization which enhances energy levels in the body. DMG HCL Background and Benefits. DMG is an abbreviation for dimethylglycine, an amino acid with the chemical formula (CH3)2NCH2COOH. It is derived from glycine, which is one of the 20 amino acids commonly used to synthesize proteins in humans. DMG was originally named vitamin B16 when it.
SAMe has been shown in clinical studies to be the fastest acting safest and possibly, most effective antidepressant ever found. One study found that 66% of patients treated with SAMe showed significant clinical improvement in depressive symptoms compared only 22% of patients given the antidepressant drug imipramine. Unlike conventional antidepressant drugs that produce adverse side effects, SAMe produces multiple health benefits and may slow the aging process.The March 1997 issue of Life Extension Magazine provides strong scientific evidence that SAMe is effective in the treatment of depression, schizophrenia, demyelination diseases, liver disease, dementia, arthritis, and other conditions. Recently, the Journal of Neurochemistry reported the brain levels of SAMe in Alzheimer's patients are severely decreased.
SAMe Costs Too Much!
SAMe is a natural metabolite of the amino acid methionine. It is sold in Europe as a drug for the treatment of depression and liver disease. The European version of SAMe is cost prohibitive for most people. The cost of an effective dose (1200-1600 mg) for treating most forms of depression and acute liver disease is $9 to $12 a day.
Unlike many drugs that have inflated prices, SAMe is genuinely very expensive to synthesize. It takes many kilos of methionine to produce 1 kilo of SAMe. Stability in manufacturing and packaging are further problems that add to the cost of SAMe.
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The Foundation is working with American laboratories to produce SAMe at a more affordable price. One of these laboratories has already developed a more cost effective synthesizing technique, but it will take time to bring SAMe into full production and, even then, SAMe may still cost more than most people can afford.A Cost Effective Way of Boosting SAMe Levels
Here's how SAMe can be boosted naturally within the body: When homocysteine is converted into methionine within the body, a by-product of this conversion is S-adenosylmethionine (SAMe). Homocysteine is amino acid, which has been linked to the development of atherosclerosis, coronary artery disease and stroke. A study in The Journal of the American Medical Association (JAMA) showed that those with high homocysteine levels had a 3.4 times greater risk of a heart attack than those with low homocysteine levels.
Conventional medical journals such as JAMA have recommended vitamin supplements such as folic acid as safe methods of lowering homocysteine. A more effective nutrient to lower homocysteine is trimethylglycine (TMG). TMG converts homocysteine into methionine and, in the process, produces S-adenosylmethionine (SAMe). Unlike the synthetic SAMe drug available from Europe, TMG is inexpensive and is readily available as a dietary supplement. In order to further describe how TMG works, we will introduce a new concept called 'methylation enhancement' and describe how this may relate to aging.
A Cell Rejuvenating Event
Methylation can be defined as the process of putting a methyl group onto a DNA molecule. Published research shows three specific benefits of enhancing methylation:
- Methylation lowers dangerous homocysteine levels, thus lowering the risk of heart disease and stroke. Methylation is the primary process by which homocysteine is transformed into nontoxic compounds such as SAMe.
- Methylation produces SAMe, which may have potent anti-aging effects, and has been shown to alleviate depression, remylenate nerve cells, improve Alzheimer's and Parkinson's disease patients, and protect against alcohol-induced liver injury.
- Methylation protects DNA. Methyl groups appear to prevent genes that cause diseases from being expressed. Protecting DNA may reduce the risk of genetically induced cancers in addition to slowing cellular aging.
Factors that decrease methylation include smoking, alcohol consumption, high fat diets, birth control pills and aging. As animals age, their methylation activity declines progressively. This decline in methylation is directly related to the physical decline associated with aging. Published research shows that 'methylation' is related to a variety of disease states including cardiovascular disease, cancer, liver disease, and neurological disorders.
TMG and SAMe both facilitate youthful methylation metabolism. Enhancing methylation not only protects against many diseases, but may make people feel younger. Optimal methylation occurs in young women of child bearing age, but even some of these women suffer from a methylation deficiency that can produce a wide range of disease states. These women can be helped by following a methylation enhancing program.
Methylation - Enhancing Protocol
Trimethylglycine (TMG) is the most effective methylation enhancing agent known. After TMG converts toxic homocysteine into methionine and SAMe, it becomes DMG (dimethylglycine), the first nutrient performance enhancer sold in the United States in health food stores.
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TMG is extracted from sugar beets. It has a distinctive taste that is mildly sweet with a mild aftertaste. TMG is also known as glycine betaine. Some vitamin companies confuse 'betaine hydrochloride' with glycine betaine (TMG). Betaine HCL does not provide the methylation enhancement of TMG and could elevate stomach acidity in some people. There are no reports of side effects with TMG other than brief muscle tension headaches if it is taken in large quantities without food.Fortunately, the cost of 99% pure trimethylglycine is low, thus enabling Foundation members to take high enough doses of TMG to significantly enhance methylation and SAMe levels.
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Foundation members have been obtaining potent doses of methylation enhancing nutrients in LIFE EXTENSION MIX,LIFE EXTENSION BOOSTER and CHLOROPHYLLIN. These formulas include the maximum amount of folic acid permitted by the FDA (for pregnant women). Other methylation enhancing nutrients are vitamin B12 and choline. (Vitamin B6 lowers homocysteine levels via a different mechanism than methylation enhancement.)
Studies show that while folic acid can lower homocysteine levels in most people, TMG can cause homocysteine to disappear from plasma after one to three months of administration. TMG stimulates methylation more effectively than folic acid and other vitamins.
A minimum effective dose of TMG for homocysteine reduction is 500- 1,000 mg a day. Optimal doses for methylation enhancement and SAMe elevation are about 3,000 mg a day. In some studies, 6,000 mg a day of TMG were used.
Important note: In a minority of people who suffer from elevated homocysteine, it is necessary B6. These people lack an enzyme required to convert homocysteine into methionine and SAMe. The doses of vitamin B6 required are 500 to 1,500 mg a day. This much vitamin B6 may cause peripheral nerve damage if taken over a multi-year period of time. Other B-complex vitamins, magnesium, carnitine, omega 3 fatty acids, and alpha lipoic acid may reduce the risk of nerve damage in those have to take high doses of vitamin B6 to keep homocysteine levels within a safe range.DMG: An All-Natural Wellness Builder
by Roger V. Kendall, Ph.D.
Dimethylglycine (DMG) is a relatively small molecule with an amazing power to change and improve health, well-being, and vitality in a person's life.
A natural substance found in certain foods like meat (liver), beans, seeds, and grains, DMG is an intermediary metabolite—meaning it is rapidly broken down into other useful substances your body requires. DMG, which affects many metabolic pathways within the cell, is also produced in small amounts by humans and animals. Officially named N, N-Dimethylglycine, DMG is related to the amino acid, glycine, whose two hydrogen atoms have been replaced with methyl (CH3) groups on its nitrogen atom. Research shows it to be physiologically active and important to cell metabolism, as well as a supplier of essential methyl groups for modifying, building, and detoxifying many components in the body.
Over 25 years of research and clinical studies have demonstrated DMG, as a nutritional supplement, has many positive effects, including stress reduction, improved athletic and sexual performance, and enhanced cardiovascular, brain, and immune functions. An adaptogen, DMG works with other co-factors in the body to counteract the negative effects of physical, emotional, and metabolic stress and to help prevent and overcome degenerative diseases. It can also normalize physiological functions and help maintain homeostasis (balance) within the body. These physiological functions include the regulation of blood glucose levels, immune response, blood pressure, hypoxic or low-oxygen conditions, hormone and cholesterol levels, as well as those of important biologically active molecules like SAMe, glutathione, and creatine.
Studies also show DMG:
- Provides useful building blocks for the biosynthesis of vitamins, hormones, neurotransmitters, antibodies, nucleic acids, and other metabolically active molecules
- Supports all aspects of immune response by acting as an anti-viral, anti-bacterial, and anti-fungal agent
- Promotes cardiovascular functions by supporting normal triglyceride and cholesterol levels, reducing angina, improving circulation, and decreasing elevated homocysteine levels
- Improves oxygenation, thus reducing fatigue and increasing energy for improved physical and mental performance
- Supports neurological function and mental clarity by acting as a precursor to the amino acids that are building blocks for neurotransmitters
- Acts as an antioxidant against free radicals
- Supports detoxification and enhances liver function, particularly Phase II detoxification (the phase that excretes converted toxic metabolites)
Depending on the specific health problem, the recommended dosage of DMG can range from 125 mg to more than 1000 mg daily. If you are dealing with a serious health problem, always be sure to consult with your health care practitioner.
Continued research with this nutrient will reveal even more about how DMG can be used effectively to combat the stresses and health problems that affect so many of us as we grow older. DMG can help you build wellness and live a more productive and healthier life.